提取濃縮設(she)(she)備采(cai)用(yong)短時(shi)間高(gao)效動態(tai)提取濃縮。該(gai)設(she)(she)備采(cai)用(yong)電(dian)加熱方式，自動化(hua)程度高(gao)。儲罐配有符合GMP醫療標(biao)準的CIP清(qing)潔設(she)(she)備。該(gai)設(she)(she)備主要適用(yong)于(yu)大學、研究所(suo)、公司和機構的實(shi)驗室研發和中小型測試(shi)生產線。其工作(zuo)原理(li)：將原料藥放入提取罐中，再添加510倍于(yu)水，乙醇，甲醇，丙酮等溶劑(ji)（根(gen)據工藝要求）。在使用(yong)前(qian)，打開萃(cui)取罐加熱系統(tong)并將萃(cui)取物加熱至(zhi)沸(fei)騰20-30分(fen)鐘。

吸濾管將三分之二的提取物泵入濃縮罐。關閉提取濃(nong)縮設備(bei)和夾套中的熱水，打開提取設備(bei)和(he)加熱系(xi)統(tong)，將濃(nong)(nong)(nong)縮(suo)(suo)(suo)汁(zhi)的(de)(de)溫度(du)保持在(zai)約80°C，真空度(du)保持在(zai)-0.05、濃(nong)(nong)(nong)度(du)高達-0.09MPA時(shi)，濃(nong)(nong)(nong)縮(suo)(suo)(suo)過(guo)程中(zhong)產生(sheng)的(de)(de)二次蒸氣會通(tong)過(guo)冷(leng)凝器和(he)冷(leng)卻器成(cheng)為冷(leng)凝物，然后作為新(xin)溶(rong)(rong)(rong)劑(ji)(ji)返回(hui)萃取(qu)(qu)(qu)(qu)(qu)罐，并作為新(xin)溶(rong)(rong)(rong)劑(ji)(ji)添(tian)加到(dao)藥物中(zhong)。新(xin)鮮溶(rong)(rong)(rong)劑(ji)(ji)從提取(qu)(qu)(qu)(qu)(qu)槽的(de)(de)底(di)部到(dao)頂部穿過(guo)藥物層。可溶(rong)(rong)(rong)成(cheng)分溶(rong)(rong)(rong)解在(zai)萃取(qu)(qu)(qu)(qu)(qu)槽中(zhong)的(de)(de)溶(rong)(rong)(rong)劑(ji)(ji)中(zhong)，萃取(qu)(qu)(qu)(qu)(qu)液通(tong)過(guo)抽濾管被吸入濃(nong)(nong)(nong)縮(suo)(suo)(suo)槽中(zhong)，濃(nong)(nong)(nong)縮(suo)(suo)(suo)產生(sheng)的(de)(de)二次蒸氣作為新(xin)的(de)(de)溶(rong)(rong)(rong)劑(ji)(ji)被送到(dao)萃取(qu)(qu)(qu)(qu)(qu)槽中(zhong)。形成(cheng)新(xin)的(de)(de)溶(rong)(rong)(rong)劑(ji)(ji)，回(hui)流萃取(qu)(qu)(qu)(qu)(qu)（無色(se)），直至完全溶(rong)(rong)(rong)解。持續濃(nong)(nong)(nong)縮(suo)(suo)(suo)直至濃(nong)(nong)(nong)縮(suo)(suo)(suo)至所需的(de)(de)比重軟膏(gao)。提取(qu)(qu)(qu)(qu)(qu)槽中(zhong)的(de)(de)無色(se)液體下次可以重復使(shi)用。對于有機溶(rong)(rong)(rong)劑(ji)(ji)萃取(qu)(qu)(qu)(qu)(qu)，添(tian)加適量的(de)(de)水，打開(kai)系(xi)統(tong)，用熱水夾套，然后回(hui)收溶(rong)(rong)(rong)劑(ji)(ji)。

1、提取(qu)濃縮(suo)設備通過驗(yan)證確(que)定提取(qu)設備每罐(guan)的(de)藥材投放量(liang)，熱回流提取(qu)原理決定了投料量(liang)要(yao)比多功能提取(qu)罐(guan)的(de)投料量(liang)大。

2、根據藥(yao)液(ye)濃(nong)度(du)(du)(du)確定(ding)開始回(hui)(hui)流(liu)的(de)時(shi)(shi)間。回(hui)(hui)流(liu)時(shi)(shi)間過(guo)早，提取液(ye)濃(nong)度(du)(du)(du)低會延長有效(xiao)提取時(shi)(shi)間，回(hui)(hui)流(liu)時(shi)(shi)間過(guo)晚，提取液(ye)濃(nong)度(du)(du)(du)飽和不利(li)于有效(xiao)成分(fen)的(de)提取，還浪費能源。應(ying)該在(zai)提取（沸騰(teng)）1 h后，將部分(fen)藥(yao)液(ye)放入濃(nong)縮罐(guan)，開始回(hui)(hui)流(liu)并(bing)計(ji)時(shi)(shi)。注意，提取罐(guan)內(nei)沸騰(teng)時(shi)(shi)要排(pai)除(chu)罐(guan)內(nei)的(de)空氣，否則罐(guan)內(nei)會產壓。

3、要(yao)對回流液(ye)的(de)(de)(de)溫(wen)度(du)(du)進(jin)行(xing)控制(zhi)(zhi)，不要(yao)過低(di)。同時要(yao)控制(zhi)(zhi)好提(ti)(ti)取(qu)(qu)罐內的(de)(de)(de)溫(wen)度(du)(du)，盡(jin)量保持(chi)恒溫(wen)。冷(leng)提(ti)(ti)（90 ℃以下(xia)）雜質少、澄(cheng)明(ming)度(du)(du)好，熱提(ti)(ti)效率高、澄(cheng)明(ming)度(du)(du)差。沸騰的(de)(de)(de)目(mu)的(de)(de)(de)是(shi)增強溶(rong)液(ye)的(de)(de)(de)擴散(san)和滲(shen)透(tou)作用，沸騰雖可以在短時間內縮小溶(rong)液(ye)的(de)(de)(de)濃(nong)度(du)(du)差，但會(hui)使許多大分(fen)子雜質溶(rong)出。回流的(de)(de)(de)主要(yao)目(mu)的(de)(de)(de)就(jiu)是(shi)在合(he)適的(de)(de)(de)溫(wen)度(du)(du)下(xia)，以滲(shen)漉的(de)(de)(de)形式，動態地降低(di)提(ti)(ti)取(qu)(qu)罐內溶(rong)液(ye)的(de)(de)(de)濃(nong)度(du)(du)差，在滲(shen)透(tou)壓的(de)(de)(de)作用下(xia)，使細胞內濃(nong)溶(rong)液(ye)不斷向外(wai)擴張，細胞外(wai)的(de)(de)(de)溶(rong)劑不斷進(jin)入細胞內。

4、確定熱回流提取設(she)備提(ti)(ti)取時間。過分提(ti)(ti)取會(hui)增(zeng)加提(ti)(ti)取液中的雜質給后期分離(li)增(zeng)加困難，時間過短則提(ti)(ti)取不完全，浪費原料(liao)（需在提(ti)(ti)取過程中檢驗溶液濃(nong)度(du)）。

5、熱回流提取設(she)備不(bu)能當(dang)多功(gong)能提(ti)取(qu)(qu)罐(guan)用，因為熱回流(liu)機組的提(ti)取(qu)(qu)罐(guan)一般采(cai)用倒錐型(xing)設計，除渣方便(bian)，但底部沒有(you)加熱。按多功(gong)能提(ti)取(qu)(qu)罐(guan)的工藝操作，藥(yao)材會(hui)在提(ti)取(qu)(qu)罐(guan)的底部形成冷堆(dui)，減(jian)少(shao)有(you)效(xiao)成分的提(ti)取(qu)(qu)量，造成藥(yao)材的浪費。

提取(qu)濃縮(suo)設備的工藝流程

提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)濃(nong)(nong)縮(suo)設(she)備(bei)(bei)多(duo)功能提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)罐(guan)(guan)的(de)加熱(re)方法。提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)水(shui)后(hou)，將(jiang)中(zhong)(zhong)(zhong)草藥(yao)原料和水(shui)放入(ru)提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)物中(zhong)(zhong)(zhong)，直接引入(ru)蒸(zheng)汽和熱(re)量，并(bing)在溫(wen)度達到提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)水(shui)平時停(ting)止。中(zhong)(zhong)(zhong)間(jian)層(ceng)被(bei)蒸(zheng)汽間(jian)接加熱(re)，使罐(guan)(guan)內溫(wen)度保持在規定范圍內。在酒精提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)過(guo)(guo)程中(zhong)(zhong)(zhong)，始(shi)終將(jiang)蒸(zheng)汽供(gong)應到儲罐(guan)(guan)的(de)中(zhong)(zhong)(zhong)間(jian)層(ceng)以進行間(jian)接加熱(re)。強制循(xun)環。提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)和濃(nong)(nong)縮(suo)器提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)過(guo)(guo)程可以使用(yong)泵(beng)迫使制藥(yao)業在制藥(yao)行業中(zhong)(zhong)(zhong)循(xun)環使用(yong)，以提(ti)(ti)(ti)(ti)(ti)高提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)效率但淀(dian)粉含(han)量高（不適用(yong)于(yu)高粘(zhan)性材料）。換句話(hua)說，藥(yao)液(ye)(ye)從罐(guan)(guan)底部(bu)的(de)液(ye)(ye)體(ti)出(chu)口流(liu)出(chu)，提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)濃(nong)(nong)縮(suo)設(she)備(bei)(bei)被(bei)藥(yao)液(ye)(ye)過(guo)(guo)濾(lv)器過(guo)(guo)濾(lv)并(bing)通(tong)過(guo)(guo)泵(beng)返回到提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)罐(guan)(guan)。提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)完成后(hou)，提(ti)(ti)(ti)(ti)(ti)取(qu)(qu)(qu)的(de)液(ye)(ye)體(ti)將(jiang)從罐(guan)(guan)底部(bu)的(de)液(ye)(ye)體(ti)出(chu)口排出(chu)，經過(guo)(guo)過(guo)(guo)濾(lv)器，然后(hou)將(jiang)化學溶液(ye)(ye)送(song)至下一個(ge)濃(nong)(nong)縮(suo)區進行處理(li)。

提取濃縮設(she)備的特征:

◆機組(zu)裝(zhuang)置選(xuan)材優(you)良，具效率(lv)高，操作方便，自動化程度高等優(you)點

◆內置電加熱器，無(wu)需外部加熱源

◆可以實現提取和濃縮溫(wen)度的控制(zhi)及顯示、在線(xian)檢測等(deng)

◆側蓋易打開，便于清洗

◆主要(yao)配件:提取罐、濃縮(suo)罐、攪拌電機、冷凝器、冷卻器、油水分離器、進料口、加(jia)熱器、過濾器、 溫度控(kong)制器、出(chu)料閥、機架、安(an)全閥、控(kong)制柜(ju)、真空泵(beng)等

◆內外(wai)焊縫拋光300目，三層保(bao)溫，敞開式結(jie)構

◆優良SUS304材質(zhi)，2B不銹鋼板(ban)材